Retrodialysis

Psychogenics utilizes a variety of techniques for drug delivery to administer pharmaceutical agents either systemically (intramuscular, intraperitoneal, subcutaneous, intravenous, or orally), or centrally (i.c.v.). In addition, we use retrodialysis to deliver drugs to different nuclei, such as striatum, hippocampus, and amygdala, where the drugs can directly affect the specific nuclei and bypass the blood-brain barrier, avoiding peripheral effects of systemically administered drugs. Subsequently we are able to analyze neurotransmitters in situ in the same brain region or in a different brain nuclei using double probe microdialysis.