Pharmacokinetics (PK) is an important aspect of animal studies and Psychogenics now offers a wide range of PK options which provide details on route, dosing concentration, timing etc to insure a successful subsequent study. Various routes of administration (PO, IV, SC, IM) coupled with terminal (plasma and tissue measures) or serial (plasma) collections can be tailored to provide the desired PK data.
- IV vs PO dosing comparing compound A
IV vs PO dosing comparisons provide an indication of how the fate of the drug is impacted by the dosing route. PO dosing is expected to delay delivery of the drug and this is clearly observed in the IV vs PO dosing plot below.
IV vs PO dosing (1 mg/kg) in Sprague Dawley rats with LCMS bioanalysis of compound A-2 in plasma following serial collection of blood over a 7 hour time course.
- PO dosing comparing analogs of compound A
Minor structural changes in compound A were also examined to determine their impact on the fate of the drug after PO dosing. Minor alterations in compound A did not result in a significant alteration of the PK data.
PO dosing (1 mg/kg) in Sprague Dawley rats with LCMS bioanalysis of compound A-1 and A-2 in plasma following serial collection of blood over a 7 hour time course.