Society for Neuroscience 2013 Archives

Evaluation of MP-10, a PDE10 inhibitor, on BACHD transgenic rats using dual recording of single units in Globus Pallidus and Subthalamic nucleus

by admin | Aug 10, 2013

S. ZHONG, G. TOMBAUGH, L. MRZLJAK, V. BEAUMONT, C. SCHMIDT, M. ZALESKA, C. CHANG, A. GHAVAM Chorea in Huntington’s disease (HD) patients might be due in part to a dysfunction of the indirect pathway (IP) of the basal ganglia. D2-expressing striatal medium spiny...

Altered neuronal activity in-vivo in subthalamic nucleus but not globus pallidus in the heterozygous z_Q175 mouse model of Huntington’s disease

by admin | Jul 25, 2013

H. LIN, S. ZHONG, S. BENT, H. S. HAIN, V. BEAUMONT, A. GHAVAMI Huntington’s disease (HD) is a lethal autosomal dominant neurodegenerative disease that leads to deficits in motor control and cognitive/psychiatric functions. Chorea, a loss of motor control that is...

Evaluation of deficits in response inhibition in the peak interval task in three mouse models of Huntington’s disease

by admin | Jun 18, 2013

S. OAKESHOTT, F. BALCI, R. PORT, J. SUTPHEN, J. BERGER, J. WATSON-JOHNSON, A. M. FARRAR, S. RAMBOZ, L. PARK, D. HOWLAND, D. BRUNNER Background: In addition to other symptom domains, Huntington’s disease (HD) is also characterized by cognitive disturbances that...

Genetic knockdown of HDAC4, or sub-chronic treatment with a novel selective Class IIa HDAC inhibitor, reverses elevated membrane excitability in striatal medium spiny neurons from R6/2 and zQ175 Huntington’s disease model mice

by admin | May 23, 2013

G. C. TOMBAUGH, S. GELMAN, A. BRADAIA, K. WADEL, V. GARDES, C. TOULLER, A. SERS, A. GHAVAMI, B. BUISSON, G. BATES, M. MIELCAREK, C. DOMINGUEZ, M. MAILLARD, V. BEAUMONT Huntington’s disease (HD) is a lethal autosomal dominant neurodegenerative disorder that leads...

Longitudinal neuromuscular responses in mdx mice challenged with or without addition of forced exercise

by admin | Apr 14, 2013

A. E. KUDWA, Y. JIMENEZ, D. GOMEZ, A. SANCHEZ, R. STEVENSON, B. ALOSIO, R. MUSHLIN, K. CIRILLO, S. RAMBOZ Duchenne muscular dystrophy (DMD) is a lethal X-linked neuromuscular disease caused by a mutation in the dystrophin gene, and the mdx mouse is the most widely...

Evaluation of MP-10, a PDE10 inhibitor, on BACHD transgenic rats using dual recording of single units in Globus Pallidus and Subthalamic nucleus

Altered neuronal activity in-vivo in subthalamic nucleus but not globus pallidus in the heterozygous z_Q175 mouse model of Huntington’s disease

Evaluation of deficits in response inhibition in the peak interval task in three mouse models of Huntington’s disease

Genetic knockdown of HDAC4, or sub-chronic treatment with a novel selective Class IIa HDAC inhibitor, reverses elevated membrane excitability in striatal medium spiny neurons from R6/2 and zQ175 Huntington’s disease model mice

Longitudinal neuromuscular responses in mdx mice challenged with or without addition of forced exercise

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